Sensible Medicine

Sensible Medicine

Aggressive Cholesterol Management

A Sensible Medicine Debate

Adam Cifu, MD's avatar
John Mandrola's avatar
Vinay Prasad's avatar
Adam Cifu, MD, John Mandrola, and Vinay Prasad
May 21, 2026
∙ Paid

Vinay, John, and I recently passed around a tweet we had seen. It reflected a lot of the conversations we were hearing right after the new cholesterol guidelines were published. We thought it would be a good topic to cover. This is a design we have used in the past and expect to be using a lot in the coming months. We present a statement or question, and then we each write < 400 words without seeing what the others wrote. Hope you enjoy, and please feel free to send more topics our way.

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The Tweet

I’m 36. I’m a physician. I take a statin—and ezetimibe—every day. No symptoms. No cardiac history. Just an honest read of the evidence. Here’s what I found—and why I stopped waiting for a reason to act.

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