I'm healthy. I'm a little overweight. Should I start a GLP-1?

A first, second, and third opinion

Adam Cifu, MD, Vinay Prasad, and John Mandrola

Jun 10, 2026

∙ Paid

The next in our “1st, 2nd, and 3rd opinions” series. Same rules as always, we come up with a case or question, and then we each write < 400 words without seeing what the others wrote. Please feel free to send more topics our way.

I'm 40 years old and healthy. I exercise 5 days a week, and I don't have hypertension or diabetes. My doctor says I am good. I've got a BMI of 29 (5'10", 200 pounds). I want to start a GLP-1 as I'd love to weigh 175, like I did when I started college. Is this a good idea?

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