Love the ‘sin’ framework which I believe is just another word for ‘missing the mark’ (translation: bad aim).
Interestingly Aspirin first showed promise in preventing colon cancer in the exact same literature of Lynch Syndrome which is why USPSTF was previously excited to endorse it for ‘at least 10 years of use’ (first general population …
Love the ‘sin’ framework which I believe is just another word for ‘missing the mark’ (translation: bad aim).
Interestingly Aspirin first showed promise in preventing colon cancer in the exact same literature of Lynch Syndrome which is why USPSTF was previously excited to endorse it for ‘at least 10 years of use’ (first general population ‘study’ was retrospective cohort).
Then when finally tested in a RCT (ASPREE) the 5 year arm showed increased colorectal cancer rates (and a near significant trend towards death) in the treatment arm.
Our chains of evidence validity are so fragile that you are right to tug on them a bit. Amazing how quickly they become undone.
Love the ‘sin’ framework which I believe is just another word for ‘missing the mark’ (translation: bad aim).
Interestingly Aspirin first showed promise in preventing colon cancer in the exact same literature of Lynch Syndrome which is why USPSTF was previously excited to endorse it for ‘at least 10 years of use’ (first general population ‘study’ was retrospective cohort).
Then when finally tested in a RCT (ASPREE) the 5 year arm showed increased colorectal cancer rates (and a near significant trend towards death) in the treatment arm.
Our chains of evidence validity are so fragile that you are right to tug on them a bit. Amazing how quickly they become undone.