Very good topic. The “open artery theory” emerged in the late 80’ proposing the dominant cause of death and morbidity in acute myocardial infarction was the persistent occlusion of the culprit artery. It was tested and confirmed by the early thrombolysis studies (ISIS-2, etc). Once a patient has the artery opened, all other treatments be…
Very good topic. The “open artery theory” emerged in the late 80’ proposing the dominant cause of death and morbidity in acute myocardial infarction was the persistent occlusion of the culprit artery. It was tested and confirmed by the early thrombolysis studies (ISIS-2, etc). Once a patient has the artery opened, all other treatments became marginal interventions, with little effect on mortality. Hence, B-blockers value as an additional therapy has to be tested again in the reperfusion era. (I think they were!)
Very good topic. The “open artery theory” emerged in the late 80’ proposing the dominant cause of death and morbidity in acute myocardial infarction was the persistent occlusion of the culprit artery. It was tested and confirmed by the early thrombolysis studies (ISIS-2, etc). Once a patient has the artery opened, all other treatments became marginal interventions, with little effect on mortality. Hence, B-blockers value as an additional therapy has to be tested again in the reperfusion era. (I think they were!)
On marginalism:
https://doi.org/10.17267/2675-021Xevidence.2022.e4722