My take was slightly different, because Foy did say that he would tell a patient if they wanted to do the most possible to prevent a CVE, he would recommend a statin, and Mandrola also seems to think statins are both safe and effective. What I'm hearing is that they respect patient autonomy/self-determination, and that after they go over…
My take was slightly different, because Foy did say that he would tell a patient if they wanted to do the most possible to prevent a CVE, he would recommend a statin, and Mandrola also seems to think statins are both safe and effective. What I'm hearing is that they respect patient autonomy/self-determination, and that after they go over risks/benefits of statins, they have no problem allowing the patient to decide, and won't pressure them to take a statin the way many other doctors will. While they are often skeptical of other interventions and about the bias in industry sponsored research, to me they do not appear to be skeptical about the efficacy or safety of statins. I hope they do an entire podcast on statins in the future. I would especially like to know how statins are shutting down atherosclerosis when research shows CAC scores go up after starting a statin. The rationale is that statins calcify soft plaque, making it more stable. Great. But you still have plaque! I'm not sure if statins actually reduce plaque, and the small ARR might be due to its anti-inflammatory effect, and there are other ways to lower inflammation. It seems to me there is still A LOT we still don't know, and as Andrew said, chronic disease in humans is complex and multifactorial.
My take was slightly different, because Foy did say that he would tell a patient if they wanted to do the most possible to prevent a CVE, he would recommend a statin, and Mandrola also seems to think statins are both safe and effective. What I'm hearing is that they respect patient autonomy/self-determination, and that after they go over risks/benefits of statins, they have no problem allowing the patient to decide, and won't pressure them to take a statin the way many other doctors will. While they are often skeptical of other interventions and about the bias in industry sponsored research, to me they do not appear to be skeptical about the efficacy or safety of statins. I hope they do an entire podcast on statins in the future. I would especially like to know how statins are shutting down atherosclerosis when research shows CAC scores go up after starting a statin. The rationale is that statins calcify soft plaque, making it more stable. Great. But you still have plaque! I'm not sure if statins actually reduce plaque, and the small ARR might be due to its anti-inflammatory effect, and there are other ways to lower inflammation. It seems to me there is still A LOT we still don't know, and as Andrew said, chronic disease in humans is complex and multifactorial.