As several years on his own stack have shown, Vinay never reads user comments...never. Adam and John sometimes do and may respond. This is a good idea but as several other subscribers have noted, the stack authors generally hew to the ideas of those they know for ideas. The stack is still of high quality -- but one would not call it responsive.
What is the deal with Depakote? It seems common knowledge that it is a mood stabilizer; but when you read the DOJ settlement from 2012 (which includes many internal emails and communications) it seems they were never able to show that feature in a clinical trial. Furthermore, the bipolar trial hit its target, but too many people committed suicide in the depakote arm compared to the lithium arm. (Some people wrote articles at the time that were critical about the design of that trial.)
It is worth noting that depakote seems effective for seizure control. But aside from epilepsy, should it be used a general mood stabilizer?
(Thank you for responding to my earlier post, Dr. Cifu. I hope you have a nice Thanksgiving. I thought this Depakote thing might be fun, because the Abbot Lab internal emails have such anguish about the clinical trial designs.)
Can we please have a thread where the listeners suggest topics?
We are absolutely open to suggestions or anyone writing a piece and submitting. Please email me.
How can we find your email address?
adam.cifu@gmail.com
As several years on his own stack have shown, Vinay never reads user comments...never. Adam and John sometimes do and may respond. This is a good idea but as several other subscribers have noted, the stack authors generally hew to the ideas of those they know for ideas. The stack is still of high quality -- but one would not call it responsive.
Here is the question I am going to send Dr. Cifu:
What is the deal with Depakote? It seems common knowledge that it is a mood stabilizer; but when you read the DOJ settlement from 2012 (which includes many internal emails and communications) it seems they were never able to show that feature in a clinical trial. Furthermore, the bipolar trial hit its target, but too many people committed suicide in the depakote arm compared to the lithium arm. (Some people wrote articles at the time that were critical about the design of that trial.)
It is worth noting that depakote seems effective for seizure control. But aside from epilepsy, should it be used a general mood stabilizer?
(Thank you for responding to my earlier post, Dr. Cifu. I hope you have a nice Thanksgiving. I thought this Depakote thing might be fun, because the Abbot Lab internal emails have such anguish about the clinical trial designs.)
We are absolutely open to suggestions or anyone writing a piece and submitting. Please email me.