I agree with much of your criticism. My comment is truncated in that the various aspects of potential proof are omitted…and “true” proof is very elusive, even in all the supposed “knowns” upon which we’ve based so much in our rather clunky modern medicine. I didn’t even cite some of the articles, studies, trials upon which I am offering …
I agree with much of your criticism. My comment is truncated in that the various aspects of potential proof are omitted…and “true” proof is very elusive, even in all the supposed “knowns” upon which we’ve based so much in our rather clunky modern medicine. I didn’t even cite some of the articles, studies, trials upon which I am offering evidence, maybe not technically “TRUTH,” but definitely questioning what we think we know and offering alternative narratives of both etiology and treatment of common chronic diseases, including CVD.
I mean, where’s the proof that cholesterol causes plaques? Is this true? (nope)
Actually, no proof, and when faced with purely fatty plaques, cardiologists figure they’re bad, in spite of evidence to the contrary. Without calcium, they are benign.
Sooo much money, hubris, careers, reputations are based in really misguided ideas.
How do we reconcile that most folks who suffer an event have so-called “normal” cholesterol levels?
A search of the literature regarding such as CAC, calcium, microcalcifications, vitamin K/K2, matrix gla protein, UBIAD1, etc - alone and in combination - offer some real insights.
See: Historical Review of the Use of Relative Risk Statistics in the Portrayal of the Purported Hazards of High LDL Cholesterol and the Benefits of Lipid-Lowering Therapy (2023)
Or here’s a fun, new alternative diabetes insight:
Revisiting the interconnection between lipids and vitamin K metabolism: insights from recent research and potential therapeutic implications: a review
Once cholesterol was blamed for plaques, we were stuck. Stuck, stuck, stuck. We hit on an answer to a problem: statins. Only this was and is incorrect. Statins suffer the statistical manipulations cited in that Historical Review mentioned above and harms are understated. There are clues about real causes of cardiovascular events bc we know that a zero CAC offers a 15 year warranty from death by all causes (!). But no drugs address CAC, so there’s push back against measuring that; no answer, why look? Contrarily, even if the answer is “bad,” we can be persuaded to believe and I could cite several specifics in a variety of specialties as examples.
Instead of seeing this CAC as something to attack, let’s understand its etiology. That will, upon enough literature searching, lead to microcalcifications. Which will lead to the hugely important and vastly misunderstood topic of vitamin K. Huge. Complex. Inchoate. But once we saw vitamin K as only about coagulation, we got stuck (see a pattern?).
We are now facing some huge health woes by way of epidemic non communicable diseases and modern medicine, stuck as it is, is not addressing them.
As a small add-on : cancer.
A Japanese man with HCC quit responding to conventional therapy, had many metastases. So they gave him a vitamin K2 analogue. No bad effects. All metastases disappeared…complete response.
Search cancer and vitamin K2. Crazy.
“Truth [and proof] may be found at the bottom of a bottomless well.”
I agree with much of your criticism. My comment is truncated in that the various aspects of potential proof are omitted…and “true” proof is very elusive, even in all the supposed “knowns” upon which we’ve based so much in our rather clunky modern medicine. I didn’t even cite some of the articles, studies, trials upon which I am offering evidence, maybe not technically “TRUTH,” but definitely questioning what we think we know and offering alternative narratives of both etiology and treatment of common chronic diseases, including CVD.
I mean, where’s the proof that cholesterol causes plaques? Is this true? (nope)
Actually, no proof, and when faced with purely fatty plaques, cardiologists figure they’re bad, in spite of evidence to the contrary. Without calcium, they are benign.
Sooo much money, hubris, careers, reputations are based in really misguided ideas.
How do we reconcile that most folks who suffer an event have so-called “normal” cholesterol levels?
A search of the literature regarding such as CAC, calcium, microcalcifications, vitamin K/K2, matrix gla protein, UBIAD1, etc - alone and in combination - offer some real insights.
See: Historical Review of the Use of Relative Risk Statistics in the Portrayal of the Purported Hazards of High LDL Cholesterol and the Benefits of Lipid-Lowering Therapy (2023)
Or here’s a fun, new alternative diabetes insight:
https://pubmed.ncbi.nlm.nih.gov/37171959/
Vitamin K-dependent carboxylation regulates Ca2+ flux and adaptation to metabolic stress in β cells
(Note new, larger than usual, vitamin K-dependent proteins in the ER of those beta cells)
Or this:
https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-023-00779-4
Revisiting the interconnection between lipids and vitamin K metabolism: insights from recent research and potential therapeutic implications: a review
Once cholesterol was blamed for plaques, we were stuck. Stuck, stuck, stuck. We hit on an answer to a problem: statins. Only this was and is incorrect. Statins suffer the statistical manipulations cited in that Historical Review mentioned above and harms are understated. There are clues about real causes of cardiovascular events bc we know that a zero CAC offers a 15 year warranty from death by all causes (!). But no drugs address CAC, so there’s push back against measuring that; no answer, why look? Contrarily, even if the answer is “bad,” we can be persuaded to believe and I could cite several specifics in a variety of specialties as examples.
Instead of seeing this CAC as something to attack, let’s understand its etiology. That will, upon enough literature searching, lead to microcalcifications. Which will lead to the hugely important and vastly misunderstood topic of vitamin K. Huge. Complex. Inchoate. But once we saw vitamin K as only about coagulation, we got stuck (see a pattern?).
We are now facing some huge health woes by way of epidemic non communicable diseases and modern medicine, stuck as it is, is not addressing them.
As a small add-on : cancer.
A Japanese man with HCC quit responding to conventional therapy, had many metastases. So they gave him a vitamin K2 analogue. No bad effects. All metastases disappeared…complete response.
Search cancer and vitamin K2. Crazy.
“Truth [and proof] may be found at the bottom of a bottomless well.”
A Civil Action