I sure posted a lot, didn’t I? So not sure what you’re interested in learning more about. I gave some links that support some of my claims here in subsequent posts, but these are a few supportive articles about claims for which I didn’t post anything to date:
1) microcalcifications are newly seen via new technology and appear to…
I sure posted a lot, didn’t I? So not sure what you’re interested in learning more about. I gave some links that support some of my claims here in subsequent posts, but these are a few supportive articles about claims for which I didn’t post anything to date:
1) microcalcifications are newly seen via new technology and appear to lead to what will be CAC
Thyroid Hormone Targets Matrix Gla Protein Gene Associated With Vascular Smooth Muscle Calcification (2005)
[This is where the various medical specialties tend to communicate amongst themselves poorly, not really understanding how they are akin to the story about the blind men and the elephant. Endocrinologists have assumptions about T3 by way of conversion by deiodinases, they know how thyroid patients are at increased risk of cardiovascular events, they even know that calcium dysregulation is coexisting with thyroid diseases, but how many cardiologists and endocrinologists know what this paper implies? We can’t measure on-site T3, so we assume serum levels tell us that. But, since rodents are ‘willing’ to die, so we can test this assumption, we know that T4 to T3 conversion differs among tissues and is the diversity is not represented by serum levels. Humans? And hypothyroid patients on standard-of-care T4 monotherapy have different serum ratios of T3/T4 compared to euthroid patients. Cardiologists figure endocrinology knows thyroid functioning, based largely on TSH guidelines, but:
Hi KittyB,
I sure posted a lot, didn’t I? So not sure what you’re interested in learning more about. I gave some links that support some of my claims here in subsequent posts, but these are a few supportive articles about claims for which I didn’t post anything to date:
1) microcalcifications are newly seen via new technology and appear to lead to what will be CAC
https://www.sciencedirect.com/science/article/abs/pii/S1050173818300574?via%3Dihub
Coronary arterial calcification: A review of mechanisms, promoters and imaging (2018)
https://www.sciencedirect.com/science/article/pii/S1936878X1731001X?via%3Dihub
Coronary Artery Calcification and its Progression: What Does it Really Mean? (2018)
https://www.mdpi.com/2075-4418/9/4/125
Coronary Artery Microcalcification: Imaging and Clinical Implications (2019)
2) matrix gla protein synthesis is directly related to the transformation of the thyroid hormone, T4, into the active hormone, T3:
https://www.ahajournals.org/doi/10.1161/01.RES.0000181431.04290.bd?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
Thyroid Hormone Targets Matrix Gla Protein Gene Associated With Vascular Smooth Muscle Calcification (2005)
[This is where the various medical specialties tend to communicate amongst themselves poorly, not really understanding how they are akin to the story about the blind men and the elephant. Endocrinologists have assumptions about T3 by way of conversion by deiodinases, they know how thyroid patients are at increased risk of cardiovascular events, they even know that calcium dysregulation is coexisting with thyroid diseases, but how many cardiologists and endocrinologists know what this paper implies? We can’t measure on-site T3, so we assume serum levels tell us that. But, since rodents are ‘willing’ to die, so we can test this assumption, we know that T4 to T3 conversion differs among tissues and is the diversity is not represented by serum levels. Humans? And hypothyroid patients on standard-of-care T4 monotherapy have different serum ratios of T3/T4 compared to euthroid patients. Cardiologists figure endocrinology knows thyroid functioning, based largely on TSH guidelines, but:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287526/
Is a Normal TSH Synonymous With “Euthyroidism” in Levothyroxine Monotherapy? (2016)]
Other claims, with supportive links, are in my other posts.
I hope this answers your request!