In my book, The Cholesterol Delusion, I compared the figures from the five major statin trials with those from the British Medical Journal's "Collaborative Overview of Randomized Trials of Anti-Platelet Therapy" published in 1994. Most of those trials used low dose aspirin. Total mortality was 6.6% in the statin group compared to 8.2% in…
In my book, The Cholesterol Delusion, I compared the figures from the five major statin trials with those from the British Medical Journal's "Collaborative Overview of Randomized Trials of Anti-Platelet Therapy" published in 1994. Most of those trials used low dose aspirin. Total mortality was 6.6% in the statin group compared to 8.2% in the control for an absolute risk reduction of 1.6%. Total mortality was 6.8% in the anti-platelet therapy group and 7.9% for their controls for an absolute risk reduction of 1.1%. The figures were similar for the other common endpoint---nonfatal MI. I doubt that any of the differences are of any real significance but it does indicate that, if there is an anti-inflammatory effect, statins provide nothing more than low dose aspirin. Of course, one could also argue that the small differences could be due to anti-thrombotic effect as well.
In my book, The Cholesterol Delusion, I compared the figures from the five major statin trials with those from the British Medical Journal's "Collaborative Overview of Randomized Trials of Anti-Platelet Therapy" published in 1994. Most of those trials used low dose aspirin. Total mortality was 6.6% in the statin group compared to 8.2% in the control for an absolute risk reduction of 1.6%. Total mortality was 6.8% in the anti-platelet therapy group and 7.9% for their controls for an absolute risk reduction of 1.1%. The figures were similar for the other common endpoint---nonfatal MI. I doubt that any of the differences are of any real significance but it does indicate that, if there is an anti-inflammatory effect, statins provide nothing more than low dose aspirin. Of course, one could also argue that the small differences could be due to anti-thrombotic effect as well.