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Frank Harrell's avatar

I have to have a friendly disagreement about that. I think there is a chance that NNT is misleading even under ideal situations such as primary prevention. That's because people with mild risk factors may have NNT that is 10 fold greater than those with serious risk factors. NNT uses averages and may not apply to anyone. Primary prevention is best served by focusing on those with more risk, in some cases.

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