For all the women more concerned about HRT than maybe the overall point of this writing, I'm not seeing what type of HRT was administered. Premarin and estradiol are definitely different drugs. Within a few months of a hysterectomy, premarin caused deep indentations in nails and my hair continued to fall out in large amounts, for month…
For all the women more concerned about HRT than maybe the overall point of this writing, I'm not seeing what type of HRT was administered. Premarin and estradiol are definitely different drugs. Within a few months of a hysterectomy, premarin caused deep indentations in nails and my hair continued to fall out in large amounts, for months after the surgery. A friend educated me about the horse urine used in the drug, the side affects and about plant based estrogen. The estradiol had no side affects (for 25 years). This is anecdotal and probably doesn't apply to a majority of women, but if you are in need of HRT for whatever reason, the information may be helpful.
I fully agree. Transdermal bioidentical estrogens plus progesterone and testosteone have been a godsend for me for the last 20 years (study n=1). Since the formula is compounded, it can be tweaked as necessary for best results.
For a comprehensive article and very lengthy annotated "links and references" section, see "Bioidentical Hormone Estrogen Prevents Heart Disease," March 15 2013, by Jeffrey Dach, MD.
Abstract [excerpts:] "Conventional hormone replacement therapy results in increased thrombotic events, and an increased risk of breast cancer and dementia as evidenced in large prospective clinical trials including Heart and Estrogen/Progestin Replacement Study I and the Women's Health Initiative. A possible mechanism for these adverse events is the unfavorable net effects of conjugated equine estrogens and medroxyprogesterone acetate on the hemostatic balance and inflammatory and immune factors....
"Subjects receiving compounded transdermal bioidentical hormone therapy showed significant favorable changes in: Greene Climacteric Scale scores, Hamilton Anxiety Scale, Hamilton Depression Scale, Visual Analog Pain Scale, fasting glucose, fasting triglycerides, MMP-9, C-reactive Protein, fibrinogen, Factor VII, Factor VIII, Insulin-Like Growth Factor 1, and health outcomes of co-morbidities and a number of prescribed medications.
"Antithrombin III levels were significantly decreased at 36 months. All other measures did not exhibit significant effects. Administration of compounded transdermal bioidentical hormone therapy in doses targeted to physiologic reference ranges administered in a daily dose significantly relieved menopausal symptoms in peri/postmenopausal women. Cardiovascular biomarkers, inflammatory factors, immune signaling factors, and health outcomes were favorably impacted, despite very high life stress, and home and work strain in study subjects. The therapy did not adversely alter the net prothrombotic potential, and there were no associated adverse events."
For all the women more concerned about HRT than maybe the overall point of this writing, I'm not seeing what type of HRT was administered. Premarin and estradiol are definitely different drugs. Within a few months of a hysterectomy, premarin caused deep indentations in nails and my hair continued to fall out in large amounts, for months after the surgery. A friend educated me about the horse urine used in the drug, the side affects and about plant based estrogen. The estradiol had no side affects (for 25 years). This is anecdotal and probably doesn't apply to a majority of women, but if you are in need of HRT for whatever reason, the information may be helpful.
I fully agree. Transdermal bioidentical estrogens plus progesterone and testosteone have been a godsend for me for the last 20 years (study n=1). Since the formula is compounded, it can be tweaked as necessary for best results.
For a comprehensive article and very lengthy annotated "links and references" section, see "Bioidentical Hormone Estrogen Prevents Heart Disease," March 15 2013, by Jeffrey Dach, MD.
https://jeffreydachmd.com/bioidentical-hormone-estrogen-prevents-heart-disease/
Also see Int J Pharm Compd. 2013 Jan-Feb;17(1):74-85.
https://pubmed.ncbi.nlm.nih.gov/23627249/
Abstract [excerpts:] "Conventional hormone replacement therapy results in increased thrombotic events, and an increased risk of breast cancer and dementia as evidenced in large prospective clinical trials including Heart and Estrogen/Progestin Replacement Study I and the Women's Health Initiative. A possible mechanism for these adverse events is the unfavorable net effects of conjugated equine estrogens and medroxyprogesterone acetate on the hemostatic balance and inflammatory and immune factors....
"Subjects receiving compounded transdermal bioidentical hormone therapy showed significant favorable changes in: Greene Climacteric Scale scores, Hamilton Anxiety Scale, Hamilton Depression Scale, Visual Analog Pain Scale, fasting glucose, fasting triglycerides, MMP-9, C-reactive Protein, fibrinogen, Factor VII, Factor VIII, Insulin-Like Growth Factor 1, and health outcomes of co-morbidities and a number of prescribed medications.
"Antithrombin III levels were significantly decreased at 36 months. All other measures did not exhibit significant effects. Administration of compounded transdermal bioidentical hormone therapy in doses targeted to physiologic reference ranges administered in a daily dose significantly relieved menopausal symptoms in peri/postmenopausal women. Cardiovascular biomarkers, inflammatory factors, immune signaling factors, and health outcomes were favorably impacted, despite very high life stress, and home and work strain in study subjects. The therapy did not adversely alter the net prothrombotic potential, and there were no associated adverse events."