I spent 34 years performing organ transplant compatibility testing in 2 major academic hospitals: 1 adult & 1 pediatric. In 2015 I came across an unusual pattern in a patient's antibodies, those which cause organ rejection and are allegedly and historically attributed to exposure to mismatched blood transfusions, transplanted organs or p…
I spent 34 years performing organ transplant compatibility testing in 2 major academic hospitals: 1 adult & 1 pediatric. In 2015 I came across an unusual pattern in a patient's antibodies, those which cause organ rejection and are allegedly and historically attributed to exposure to mismatched blood transfusions, transplanted organs or pregnancy. I just published this work. I was fired for pursuing it (that's not the narrative that was spun to justify it). The combination of EBV and a 2nd virus (superinfection) provides the immune system with a "confusing" state in which it tries to attack components from both viruses simultaneously. The response is called polyspecific. I still have to finish proving it experimentally, but I provide compelling in silico data. These antibodies developed either from superinfection or EBV infection plus vaccination. There was no doubt, from data I could not publish but observed, that the influenza vaccine was responsible for at least 30% transplant rejections. https://doi.org/10.1016/j.trim.2025.102197. It's time to start following the science and put money toward that research. HLA are associated with more diseases than any other region of the human genome. And I just opened the door to Pandora's box.
I spent 34 years performing organ transplant compatibility testing in 2 major academic hospitals: 1 adult & 1 pediatric. In 2015 I came across an unusual pattern in a patient's antibodies, those which cause organ rejection and are allegedly and historically attributed to exposure to mismatched blood transfusions, transplanted organs or pregnancy. I just published this work. I was fired for pursuing it (that's not the narrative that was spun to justify it). The combination of EBV and a 2nd virus (superinfection) provides the immune system with a "confusing" state in which it tries to attack components from both viruses simultaneously. The response is called polyspecific. I still have to finish proving it experimentally, but I provide compelling in silico data. These antibodies developed either from superinfection or EBV infection plus vaccination. There was no doubt, from data I could not publish but observed, that the influenza vaccine was responsible for at least 30% transplant rejections. https://doi.org/10.1016/j.trim.2025.102197. It's time to start following the science and put money toward that research. HLA are associated with more diseases than any other region of the human genome. And I just opened the door to Pandora's box.