The problem witn evidence based medicine and guidelines is that they have not be taken as "laws".
HF is an excellent example about treatment and reproducibility: one question. The evidence favoring the use of ARNI is the same than with ACEi? Another one, the up titriation concept developed with ACEi and beta blockers…
The problem witn evidence based medicine and guidelines is that they have not be taken as "laws".
HF is an excellent example about treatment and reproducibility: one question. The evidence favoring the use of ARNI is the same than with ACEi? Another one, the up titriation concept developed with ACEi and beta blockers is completely over in order to favor the adition of ARNI an Gliflozins? Do we throw away decades of investigation ?
Interesting results...
The problem witn evidence based medicine and guidelines is that they have not be taken as "laws".
HF is an excellent example about treatment and reproducibility: one question. The evidence favoring the use of ARNI is the same than with ACEi? Another one, the up titriation concept developed with ACEi and beta blockers is completely over in order to favor the adition of ARNI an Gliflozins? Do we throw away decades of investigation ?
The Paradigm HF study which championed Entresto is one of Vinay Prasad's teaching examples of a weak study with inappropriate conclusions.
https://www.youtube.com/watch?v=HkDMn_QP0Uk
Thank you very much for the video! Excellent analysis and criticism! We are not alone!
In my practice I still use ACEi as first choice.