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Jay Kanta's avatar

Sounds like being a right-winger is more of your thing than being science-minded.

That's fine, but you should be honest. You're just making excuses for Trump and the MAGA cult.

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Clayton Mansel's avatar

It's hardly "holding my nose" to demand that a report coming down from the world's preeminent biomedical research agency be held to the same basic standard as an undergraduate biology essay. Fake citations, really? I like Jay and Vinay but others like RFK and Oz have *zero* credibility and are an embarrassment.

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Chuck Gartland's avatar

My dude thinks $$$ being “reorganized” but what is actually happening is NIH is being cut off and is in a death spiral. This admin is killing NIH not restructuring it.

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KaiKai's avatar

Thank you for a sensible discussion on prioritizing medical research funding. I was at UCSF as a surgical resident the same time you were. The number of patients with HIV was staggering especially at San Francisco General Hospital. While I did not directly treat them I was the designated surgical resident who placed chest tubes in patients with PCP pneumonia induced pneumothorax. I started putting heimlich valve tubes in so patients could go home for their remaining days. By the time I finished my training including a fellowship plus a few years in a molecular lab therapies for HIV had improved. A retrovirus may very well elude development of a vaccine but thank goodness we have effective therapeutics to reduce HIV viral load to near zero. During the pandemic we failed miserably at therapeutics, essentially throwing spaghetti against the wall and hoping it would stick. If there is to be funding for infectious diseases emphasis on therapeutics against viruses is where the focus needs to be. Thanks again Dr Marine.

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Joseph Marine, MD's avatar

Thanks for your comment. It was a great time and place to train.

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April's avatar

Thank you Dr. Marine. The number in regards to funding for HIV vaccines research and Cardiovascular disease efforts should open everyone's eyes. Funding is limited and working towards supporting dis eases that the majority of people have makes sense to me. Bravo RFK jr and MAHA on this one

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David M. Schalk's avatar

Dr. Marine,

I am glad you found one thing that Mr.Kennedy did right and used your excellent academic credentials to give credence to this incredibly underwhelming unqualified individual occupying our nation’s most important public health position. He got “something “right and all of the multitudes of people who don’t have your intelligence or education will wave your editorial in their neighbors faces and tell them how smart and on base this brilliant Doctor thinks Mr. Kennedy does his job. This is the problem with MAGA and MAHA. In their world one attaboy makes up for a thousand aw heck’s. In the real world as you know, the reverse is true. All the damage caused by this man is not made up by some inadvertent brilliant blunders that you so strongly advertise. Where have you heard that more money is going to go to cardiovascular research? I would argue for more money going to prenatal care and research into decreasing infant mortality. Adding a few more years on to your fathe or uncle or even me pales in comparison with giving a mother a healthy baby and that baby the best chance to reach average US lifespan.

Unfortunately what you forgot is that even a broken clock is correct two times every day. You found one time Mr. Kennedy was correct. I wish you would spend half as much wordsge on all his mistakes. I know you don’t have enough years to live to achieve that goal.

David M. Schalk MD

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Critical Thinker's avatar

You seem oddly upset to have to admit RFK is right about cutting wasteful public research funding… 🧐

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Jay Kanta's avatar

"wasteful"

What an arse.

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Doreen Campbell's avatar

Outstanding post! Almost nobody knows the figures you quoted and it's important that the public be more educated to avoid politicization of the practice of medicine. I agree the MAHA movement has a lot of help to shake up the status quo, and can be very good for us all to embrace. I also see a lot of damage from the CVD world in my ALF business.

I didn't realize the HIV funding was still so large, so a very informative post, thank you. Re-allocation is no more and no less than correcting course, keeping the vehicle between the lines. Taxpayers should not be blinded by the spin of media - nor should patients continue to suffer when we can help them in any way.

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Jay Kanta's avatar

"I agree the MAHA movement has a lot of help to shake up the status quo, and can be very good for us all to embrace."

So you're a right winger with no education in science or medicine.

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Doreen Campbell's avatar

To you, I'm "whatever" you think I am.

So you're a left winger with an elite attitude maybe, from the opposite view... It's a shame it comes down to that divisiveness. We all have something to contribute and not for nothing, I've healed people from diabetes in their 80's and cut insulin use to 1/3, as well as had residents on many meds, anti-psychotics and all... We have made a huge difference in the healthspan of many people over the years.

Why is it that everywhere we turn, it's recommended to eat healthier, stay hydrated, exercise and many other things we specialize in... Yet to a random blog responder, I'm "A right winger with no education in science or medicine." Very sad indeed. I wish you a better day than seeing someone's opinion you disagree with, seems to have given you today.

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Gary Edwards's avatar

Renal disease seems to have lacked appropriate funding while being a big part of Medicare expenditures.

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NeverDull's avatar

Thank you for this! I have read very little about HIV in recent years and this was incredibly insightful. And for me, it underscores the constant necessity to dig a little deeper when I feel a knee-jerk opinion forming about something I hear in passing ;-)

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Rudy P Briner,MD's avatar

I assume that all who comment here have read "Sensible Medicine," before this post, and understand the very significant waste in our research dollars on faulty or inconsequential studies funded by you and me! I'm all for re-evaluation of all programs!! I am hopeful that the food chain changes proposed will be more helpful than all the research on discreet disease types! In a "perfect world(impossible)" we will not need any research! As suggested on Sensible Medicine before, we need more research to determine processes and procedures that result in better health and health care. There is tremendous knowledge that goes unused by the vast majority of the population. The knowledge far surpases our use of that knowledge. Kind of a restatement of both Charlie and Suzie preceeding comments.

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Jay Kanta's avatar

"and understand the very significant waste in our research dollars on faulty or inconsequential studies funded by you and me!"

Whine more, right winger.

Sensible Medicine is just a libertarian cult. It's not science based, it's just a bunch of anti-social right wingers that are OK with marijuana.

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Charlie Silver's avatar

Great column. I think the insight that governmental priorities can deviate widely from public needs should be generalized. This type of mismatch appears almost everywhere in the health care sector that governments control. E.g., there seems to be a consensus that we have a shortage of GPs because GP are underpaid. Accepting the premise, this is another mismatch. Readers of SM likely have their own favorite examples.

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Suzie  Collinson's avatar

I completely agree with the redistribution of funds. I do, however, believe that there is a lot of knowledge out there that’s not being used to educate the public on how to prevent CV disease. It’s largely preventable with good diet, exercise and stress mgmt. So, how about an educational approach to start.

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Teresa Benson's avatar

I'm not sure it's a lack of education. Most people know being obese and sedentary puts them at risk, but knowledge isn't enough for many.

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Benjamin Hourani's avatar

My post was written while sitting in very slow stop and go traffic. Forgive the typos

Ben Hourani MD, MBA

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Benjamin Hourani's avatar

I appreciate Dr. Marine’s opinion.

What bothers me is the quick and dirty cutting of the HIV vaccine research. I have the opportunity to spend two years at the NIH in the 1970s what people don’t understand is that in a relationship with all the departments whether it’s cancer, infectious diseases behavior, etc.

Vaccine research in HIV has yielded tremendous understanding of both the evasive nature of viruses and bacteria as well as deception that HIV seems to have regarding immunity. Great discoveries, and cancer, regarding immunity, genetics, oncology, I resulted from the understanding of the mechanisms of HIV and its resilience. Many of the nucleotides treatments that have remarkably change a uniformly lethal disease into a chronic disease with also control of person to person infection have come about as a result of understanding the biology of HI resulted from the understanding of the mechanisms of HIV and it’s resilience. Many of the nucleotides treatments that have remarkably change a uniformly lethal disease into a chronic disease with also control of person to person infection have come about as a result of understanding the biology of HIV.

What concerns me is the broad swath for anything that’s smacks of vaccine, and RFK’s, (a non physician) urgency to delete. This also melds well with the anti-DEI association of HIV with “ not – normal sex“.

Yes, there is no vaccine yet. But the ancillary plethora of knowledge in immunology, malignancy, genetics, generalized viral biology have come out of the study of this virus and the “failure“ of this research to yield a vaccine. One area of research, can complement and augment seemingly unrelated areas of research.

BTW, cardiovascular death is still the leading cause of death in this country. Yet we have no cured it have we? Using the same logic in Dr. Marine’s well written post, should we elminate all funds for cardiovascular research at the NIH? I would argue that the advances in HIV treatment that have significantly been contributed to by the vaccine research are more impressive than the advances in treatment of CV DISEASE.

Ben Hourani MD, MBA

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Michael Patmas, MD's avatar

I didn't realize we were in a "post COVID" world.

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Teresa Benson's avatar

Those of us in red states are.

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Michael Patmas, MD's avatar

The most recent publicly available estimate comes from early 2025. According to the CDC, between October 2024 and May 2025, there have been an estimated 30,000–50,000 COVID‑19 deaths in the U.S..

But heck, they don't matter. We are in a "post COVID" world now.

.

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Critical Thinker's avatar

Who wants to tell him: there has historically ALWAYS been 45000 to 70000 Flu deaths in this country also! (except in 2020 when is miraculously disappeared 😉)

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Michael Patmas, MD's avatar

Who wants to telll the uncritical nonthinker that Infuenza is not COVID and that 50,000 deaths actaully matter? SARS Cov2 is a beta coronavirus and influenza is an orthomyxovirus. They are completely unrelated taxonomically and clinically. Infuenza does kill tens of thousands of Americans annually nearly all unneccessarily because like COVID mRNA vaccination, influenza immunization reduces mortality by 90 - 95%. What troubles me more isn't the factual mistatements, it is the deep lack of concern for human suffering, the cavalier disregard for life that such an attitude displays and the ignorance of infection control. Influenza's decline in 2020 and 2021 wasn't a miracle, it was the result of the adoption of standard infection control practices. Rhinovirus nasopharyngitis was also dramatically reduced. The discipline is called Infection Prevention. It used to be called Infection Control and sadly some physicians weren't taught about it.

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Critical Thinker's avatar

Oh what an idiotic comment. That so called “infection prevention” came at the cost of long term lock downs, school closures, increase in childhood diabetes and obesity for generations, epidemic of anxiety disorders, drug use, record high 75k deaths from drug overdose, skyrocketing of suicides, domestic violence, child abuse, local businesses destroyed, financial ruin for millions..

Was it worth it?

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Michael Patmas, MD's avatar

These were the actual adverse consequences. As bad as they were, they do not compare to 1.2M dead, millions more permanently harmed and the creation of a host reservoir to ensure never ending waves of SARS Cov2. variants.

The COVID-19 lockdowns—while aimed at limiting virus transmission and preventing healthcare system collapse—had a range of documented adverse consequences. Many of these were unintentional, and their severity varied by country, region, socioeconomic status, and public health infrastructure. Below is a summary of proven or well-documented adverse consequences of lockdowns based on peer-reviewed studies and government reports:

📉 Economic Consequences

Job Loss and Income Reduction

Tens of millions lost jobs globally, especially in service, hospitality, and informal sectors.

U.S. unemployment reached nearly 15% in April 2020—the highest since the Great Depression.

Business Closures

Small and medium-sized businesses, especially in retail and food service, suffered permanent closures.

Supply Chain Disruptions

Lockdowns disrupted global supply chains, causing shortages of goods and inflationary pressures.

🧠 Mental Health and Social Isolation

Increased Depression and Anxiety

CDC (2020–2021): U.S. adults reporting symptoms of anxiety/depression rose from ~11% pre-pandemic to ~40% during lockdown periods.

Youth Mental Health Crisis

School closures and social isolation led to increased suicidal ideation, self-harm, and psychiatric emergencies among children and teens.

Substance Abuse

Significant increase in alcohol and drug use; opioid overdoses surged in many U.S. states.

🏥 Healthcare Disruption

Delayed or Missed Care

Routine screenings, elective procedures, and chronic disease management were often postponed or skipped.

Resulted in late cancer diagnoses, uncontrolled diabetes, cardiovascular complications, etc.

Reduced Vaccination Rates (Non-COVID)

Childhood immunizations for diseases like measles and polio dropped in both developing and developed countries.

📚 Educational Loss

Learning Deficits

Remote learning proved less effective, particularly for low-income, disabled, and rural students.

Studies estimate significant learning loss, especially in math and reading.

Widened Inequality

Access to digital tools, stable internet, and parental support disproportionately affected poorer students.

👨‍👩‍👧‍👦 Social and Developmental Impact

Child Development

Reduced interaction and stimulation among young children affected language development and social skills.

Domestic Violence

Lockdowns correlated with a global rise in domestic abuse reports, particularly against women and children.

🧓 Elderly Isolation

Long-term care facility lockdowns reduced COVID exposure but also led to:

Increased cognitive decline

Higher mortality from non-COVID causes

Accelerated frailty from lack of social and physical activity

🌍 Global Poverty and Malnutrition

The World Bank estimated that lockdown-related economic downturns pushed over 100 million people into extreme poverty.

Malnutrition increased in low-income countries due to disrupted food systems and school meal programs.

🚨 Civil Liberties and Political Impact

Restrictions on movement, assembly, and expression raised legal and ethical concerns in democracies and were exploited by authoritarian regimes.

Some countries used lockdowns to suppress dissent or delay elections.

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Michael Patmas, MD's avatar

Asolutely. 1.2M dead americans. More dead than we lost in combat in all wars we have ever been in. 300,000 to 400,000 were totally uneccessary deaths due to failure to immunize and follow basic infection control practices. Millions more with long COVID. But by far the most catastrophic outcome of the abandoment of infection control and vaccination was the establishment of an enormous human host reservoir willingly hosting, replicating, mutating and dissemminating new variants. We had a window of opportunity to eliminate SARS Cov2 and we blew it. Why? Because Trump was more worried about the impact on his re-election. So he ignored, marginalized and ostracized infectious disease doctors and brought in a team of unqualified people (Battacharya et al) to give him what he wanted, an alternative strategy that might save his re-election chances - the "focused protection" and "let 'er rip", "we want them infected" nonsense of the the great barringtom declaration. Sensible Medicine is supposed to be all about evidence, right? What evidence is there to support the recommendations in the GBD? None. It dosent have a single reference. The problem isn't that we tried to immunize everyone and had a lock down and required masking. Just the opposite. We should have locked down longer and harder. Mandated masking and vaccination. We put greed and Trump ahead of public health. Now we have millions of Americans incubating the next variant. Its only a matter of random chance and time before someone in the host reservoir coughs up a new variant that could kill even more than SARS Cov2 did.

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Critical Thinker's avatar

Covid death defined as death from ANY CAUSE if person had a positive pcr test within 30 days of death. You had an asymptomatic covid the died in a car accident 3 weeks later, boom. You were counted as a covid death. That is where the 1.2 million deaths comes from. Didn’t you notice how little covid deaths were elsewhere i. The world?

Because they separated dyi g from covid versus with covid. But.., hey you don’t need to use your cerebral cortex. Not sure its even functional. Just keep parroting the mainstream narrative and copy paste from chatgpt. 👍🏻

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Michael Patmas, MD's avatar

That is false. No — not every death within 30 days (or even 28 days) of a COVID-19 positive test is automatically counted as a "COVID death." It depends on location and the method of classification.

📊 US methodology

CDC/NCHS counts are based on death certificates: COVID‑19 must be listed as an underlying or contributing cause. Merely dying within 30 days of testing positive does not automatically classify it as a COVID death

cdc.gov

+15

cdc.gov

+15

cdc.gov

+15

.

Some studies use a 30‑day window after diagnosis/test to separate “COVID vs non‑COVID” deaths (by assuming any death within 30 days may be pandemic‑related), but this is for research purposes — not official death counts .

🇬🇧 UK approach

Early on, Public Health England counted deaths within 28 days of a positive test regardless of cause. From mid‑2022, the UK switched to the more accurate death certificate metric (“COVID mentioned on certificate”) as the primary method

en.wikipedia.org

+3

ukhsa.blog.gov.uk

+3

time.com

+3

.

🇺🇸 Local variations

In Massachusetts, the definition was changed multiple times — at one point, for deaths without COVID listed on the certificate, they required occurrence within 60 days of diagnosis (later reduced to 30) to be counted .

✅ Summary table

Region/Method Includes death?

CDC (US) — certificate-based ✅ If COVID listed, regardless of timing

30-day window for research purposes ❌ Only a proxy, not used for official counts

UK (28-day rule) ✅ Used earlier; now replaced by certificate method

MA (state-level tweak) ✅ if within timeframe and natural cause, depending on policy

Final word

Deaths within a set number of days after a positive COVID test may be included in some monitoring metrics or state-level definitions. However, official COVID death counts in the U.S. (and increasingly worldwide) rely on death certificates, not just timing. Early pandemic metrics using arbitrary windows (28/30/60 days) have largely been replaced or supplemented by more accurate cause‑of‑death reporting.

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Critical Thinker's avatar

That was exactly how it was defined. Your denial does not change it.

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Michael Patmas, MD's avatar

It seems you might benefit from a review of how death certificates should completed in reference to COVID. https://www.cdc.gov/nchs/covid19/coding-and-reporting.htm

https://youtu.be/5Vxf7ed3jBE

This substack, "Sensible Medicine" is yet another forum for the spread of misinformation.

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Brock Jones's avatar

Great post Dr. Marine. As Jay Bhattacharya has said since taking over, our research should match the health problems of America. We should be funding research that could help the most Americans and in areas that have historically been underfunded in relation to their prevalence in the population.

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