Everyone's so concerned about the trial design without addressing the complexity of sedation and delirium in the ICU. First time I read the trial I couldn't understand the clinical equipoise for conducting the study.
The limiting factor for time to extubation in the ICU is far more complex than drug infusion. Secondly precedex can never a…
Everyone's so concerned about the trial design without addressing the complexity of sedation and delirium in the ICU. First time I read the trial I couldn't understand the clinical equipoise for conducting the study.
The limiting factor for time to extubation in the ICU is far more complex than drug infusion. Secondly precedex can never achieve the RASS goal propofol can. You're comparing two unequal agents.
Finally, the amount of crossover in the trial made any serious data dissection moot. The only conclusion to draw is that if you need deep sedation propofol is more effective ---- but we already knew that.
Pragmatic trials CAN work when the intervention isnt messy. There's too much noise in the ICU thats why 99% of ICU trials are negative and the remaining have a fragility index in the single digits.
Everyone's so concerned about the trial design without addressing the complexity of sedation and delirium in the ICU. First time I read the trial I couldn't understand the clinical equipoise for conducting the study.
The limiting factor for time to extubation in the ICU is far more complex than drug infusion. Secondly precedex can never achieve the RASS goal propofol can. You're comparing two unequal agents.
Finally, the amount of crossover in the trial made any serious data dissection moot. The only conclusion to draw is that if you need deep sedation propofol is more effective ---- but we already knew that.
Pragmatic trials CAN work when the intervention isnt messy. There's too much noise in the ICU thats why 99% of ICU trials are negative and the remaining have a fragility index in the single digits.