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Julia's avatar

Hi everybody. Thanks for the post. I’m out here on the front line working as an internist. There is no automatic weight loss with GLP1 receptor agonists. For hundreds of years, physicians have tried to medicalize a disease that has not only a physical, but an emotional and a spiritual component. But there is a solution.

Friend of Bill W.

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Gorf's avatar
2dEdited

Love it guys. I can see your excitement about GLP1 meds. I share some, but temper it, because I can't remember a "miracle" drug that was touted as effective for many conditions which didn't end up having serious down sides. We'll see.

I agree that "telling people to just diet and exercise more" is not a useful alternative treatment. A public health intervention which requires almost everybody to adhere to is not a useful public health intervention. And it seems to generate strong moralistic reactions for some reason.

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Jeffrey COWEN's avatar

This was better than sliced bread. Excellent discussion with practical considerations.

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Jan Kramer's avatar

The GLP-1 RA group lost much more weight than the control group. Is it the drug that was responsible for the improvement or the weight loss? It sems to me that a group that lost weight without semaglutide would have been a better control group. Either weight loss through diet/exercise or bariatric surgery or both.

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