This Fortnight in Medicine VI

A “manel” reviewing trials and studies that explore the benefits and harms of hormone replacement therapy.

The Women’s Health Initiative

• Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial

• The Women's Health Initiative Randomized Trials and Clinical Practice: A Review

• The Women’s Health Initiative Hormone Therapy Trials: Update and Overview of Health Outcomes During the Intervention and Post-Stopping Phases

Meta-analysese

• A systematic review and meta-regression analysis to examine the ‘timing hypothesis’ of hormone replacement therapy on mortality, coronary heart disease, and stroke

• Mortality Associated with Hormone Replacement Therapy in

  Younger and Older Women

History: Observational HRT Data

• Postmenopausal estrogen and progestin use and the risk of cardiovascular disease

• Hormone therapy to prevent disease and prolong life in postmenopausal women