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Guidelines, Evidence-based Medicine, and the Practice of Medicine
A meandering meditation on the flaws of guidelines and how evidence often barely affects practice
17 hrs ago
•
Adam Cifu, MD
116
19
3
33:33
This Fortnight in Medicine XXIII
Listen now | Dengue Suppression by Male Wolbachia-Infected Mosquitoes
Apr 8
•
Adam Cifu, MD
,
John Mandrola
, and
Andrew J Foy
31
10
The Illusion of Progression-Free Survival
We want patients to live longer and/or better, and if that’s not the case, keep “First, do no Harm” in mind.
Apr 7
•
Dries Develtere
110
4
6
At ACC26, the HI-PEITHO Trial is in a Photo-Finish for Greatest Spin
Pulmonary embolism is a life-threatening condition that often requires more than anticoagulation. Invasive therapies hold promise but must be held to…
Apr 6
•
John Mandrola
118
18
1
A Referendum on the Self: On Entering the Medical Profession
I could have been a much better pre-med. But I don’t think it would have made me a better doctor.
Apr 4
•
Pradz Sapre
134
16
8
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Discussions
Hyponatremia, Observational Studies, and Changing Practice
and a whole lot of footnotes
Apr 3
•
Adam Cifu, MD
104
11
1
Physicians are Providers
Even if they are more than that
Mar 31
73
38
3
CHAMPION AF Breaks Almost Every Rule of Noninferiority Trial Design
Millions of people have AF and take oral anticoagulation. It's one of Medicine's most evidence-based treatments. It would take strong data to upend this…
Mar 30
•
John Mandrola
119
23
10
Another Case of Medicine Gone Wrong
A Follow-up to Friday Reflection 59
Mar 27
•
Adam Cifu, MD
146
37
2
When Is the Evidence Enough?
The Case of Anal Cancer Screening
Mar 26
•
Ken Noguchi
78
7
2
This Fortnight in Medicine XXII
Do GLP-1s help substance use disorder? Does PCI of non-culprit vessels help people with STEMI?
Mar 24
•
Adam Cifu, MD
,
John Mandrola
, and
Andrew J Foy
20
2
1
39:33
The Salt Paradox: Essential Mineral, Silent Threat, or Something In Between?
Your doctor tells you to cut back, then what?
Mar 24
•
Bobby Dubois MD, PhD
133
64
6
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Common sense and original thinking in bio-medicine
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