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This Fortnight in Medicine XXVII
An RCT of sunscreen and melanoma prevention and an observational study analyzing the risk of NAION with SGLT2-I
22 hrs ago
•
Adam Cifu, MD
,
Vinay Prasad
, and
Andrew J Foy
19
4
33:00
Good Ideas Need to Pass Muster in the RCT
The implantable loop recorder is pretty amazing little tool. It provides a lot of data. But data are not outcomes. And, as it turns out, reducing…
Jun 1
•
John Mandrola
123
10
9
May 2026
How to Keep up with the Medical Literature
The only real truism is that you learn best when you are reading about a topic that is directly related to the care of an actual patient.
May 29
•
Adam Cifu, MD
116
23
9
ChatCPR: AI’s Answer to the Question ‘When Will It Save Lives?’
In the US, fewer than 1 in 10 people who have cardiac arrest outside the hospital survive. Read this summary of a research team's attempt to use AI to…
May 28
•
John W. Ayers
101
24
3
Affirmative Action in Medical Education
Does affirmative action still have a role in medical school admissions? A Sensible Medicine Debate
May 27
•
Adam Cifu, MD
,
Vinay Prasad
, and
John Mandrola
64
32
3
When Sponsors Stop Trials Everyone Loses
The ANTHEM HFrEF trial of vagal nerve stimulation was proceeding well when the sponsor stopped the trial. The story...and some thoughts about the…
May 25
•
John Mandrola
92
8
6
Friday Reflection 60: The Brockton
A critical rotation, the details of which could not exist today.
May 22
•
Adam Cifu, MD
108
23
3
Aggressive Cholesterol Management
A Sensible Medicine Debate
May 21
•
Adam Cifu, MD
,
John Mandrola
, and
Vinay Prasad
123
45
7
This Fortnight in Medicine XXVI
Vinay, John, and Andrew Address Left Atrial Appendage Closure
May 20
•
John Mandrola
,
Vinay Prasad
, and
Andrew J Foy
45
5
54:35
The Theatre of Treatment
We cannot assume that treatment effects are observable at the individual patient level.
May 19
•
Aleksi Raudasoja
191
24
15
If not for placebo procedures, you might be getting holes drilled into your heart
Two weeks ago, I wrote about how brave orthopedic surgeons saved many people from needless knee surgery. Yet cardiologists may be the bravest group of…
May 18
•
John Mandrola
230
42
19
When does shared decision-making mean recommending ineffective therapies?
What is the differential efficacy between a good treatment and a less good treatment that allows a doctor to completely forgo discussion of the inferior…
May 15
•
Adam Cifu, MD
79
16
1
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