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The Ideal Cholesterol Level ... Depends...And Cannot Be Determined From Observational Studies
A study making the rounds on social media reports a U-shaped association between total cholesterol and survival. It's a mess.
Oct 13
•
John Mandrola
101
76
Goodharts Law and Medical School Admissions
"When a measure becomes a target, it ceases to be a good measure."
Oct 10
•
Adam Cifu, MD
94
30
A Cancellation and a Firing at Obesity
How an Editor-in-Chief gets silenced and then canceled.
Oct 9
•
Sally Satel
and
Michael Jensen
121
13
This Fortnight in Medicine X
Leucovorin & autism, GLP1s & HFrEF, a special guest, and a bit of good natured disagreement.
Oct 8
•
Adam Cifu, MD
,
John Mandrola
, and
Andrew J Foy
31
10
50:52
Part 2: The other trials of thrombolysis in acute stroke were also less than persuasive
Last week I went over NINDS. This week, let's look at the other trials of thrombolysis in acute stroke. It's an eye-opener.
Oct 6
•
John Mandrola
75
12
Beyond the Hype: Why Good Theories Aren’t Good Medicine
Keep the hype equation in mind: Cool mechanism + Compelling anecdote + Credentialed endorsement ≠ Reliable evidence.
Oct 4
•
bobby dubois
149
58
Physician expertise, advocacy, and the decline of the USPSTF
The United States Preventive Services Task Force has become both a target of and a tool for advocacy in recent years, and this has negatively impacted…
Oct 3
•
Adam Cifu, MD
78
31
September 2025
A Sensible Take on Indirects
A Sensible Medicine Guest Post
Sep 30
•
David A. Kareken
65
8
How Strong is the Evidence for Thrombolytic Therapy for Acute Stroke?
Consider this a trigger warning. I will tell this story over the coming weeks. I warn you now. You cannot unsee what I will show you.
Sep 29
•
John Mandrola
134
51
Are Major Medical Organizations Politically Partisan?
A guest post from medical Dr. Ben Knudsen and colleagues describing their peer-reviewed political analysis of policy statements from US professional…
Sep 28
•
Ben Knudsen
158
115
Friday Reflection 54: The Extra-clinical Curbside
This is just a really hard job.
Sep 26
•
Adam Cifu, MD
101
39
Observational Studies in Pregnancy, Autism, and Politics: What Could Possibly Go Wrong?
We are no closer to knowing the cause of autism. We are no closer to understanding how to decrease the incidence of autism. We are further from people…
Sep 25
•
Adam Cifu, MD
157
43
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