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FAME-2: One of cardiology's most influential trials, and, one of its most flawed
Few trials illustrate the need for blinding more than FAME-2. You won't believe what I will show you today.
3 hrs ago
•
John Mandrola
73
8
2
When to treat (or not treat) a high cholesterol
Drs Andrew Foy and Venk Murthy help me sort out a controversial post on X about not treating a person with a high cholesterol but very low estimated…
24 hrs ago
•
John Mandrola
84
34
4
39:51
Learning Medicine Requires Learning a New Language
Repurposed medicalese
Jan 18
•
Adam Cifu, MD
81
27
3
Publish Peer Reviews!
...and three other suggestions improve the quality of the medical literature
Jan 16
•
Adam Cifu, MD
42
11
6
The Best Studies of 2025 for Hospital Medicine
What changed practice, what confirmed it, and what absolutely should not
Jan 15
•
Anil Makam, MD, MAS
90
17
6
This Fortnight in Medicine XVII
Carotid revascularization, vagal nerve simulation, and some friendly disagreement.
Jan 14
•
Adam Cifu, MD
,
John Mandrola
, and
Andrew J Foy
26
2
1
45:03
2024-2025 COVID-19 Vaccine Effectiveness in Pediatric Patients: A Response
More discussion of the recent MMWR report of COVID-19 vaccine effectiveness in the pediatric population.
Jan 13
•
Matthew Decker
58
23
1
Food may be medicine but it is not an easy one to give nor is it very effective
We here at Sensible Medicine love randomized trials, but they don't always answer important questions especially when Medicine leaves its area of…
Jan 12
•
John Mandrola
118
32
4
An Important Article?
What a positive study of vagal nerve stimulation in rheumatoid arthritis might tell us about the doctor patient relationship.
Jan 9
•
Adam Cifu, MD
89
11
5
Why Healthcare Commentators (and Doctors) are Afraid of the Free-Market
Our view of a moral doctor is anti-free-market, and that needs to change
Jan 8
•
Colleen Smith, MD
and
Reinier Schuur
110
82
12
A Trial of a Novel modRNA Flu Shot: Not So Hot
We are pleased to publish this guest critical appraisal of a recent influenza vaccine RCT--from Johns Hopkins cardiologist, Dr Joseph Marine
Jan 7
•
Joseph Marine, MD
232
39
14
Who Do You Want at a Family Picnic?
If we want nice things, like functional primary care, we need to pay for them.
Jan 6
•
Bradley Flansbaum
107
15
4
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