Sitemap - 2026 - Sensible Medicine
Andrew Foy says there is efficacy-effectiveness gap: is he right?
I can’t seem to ignore the longevity gurus
A Cautionary Tale of Clinical (Mis)translation
Should Doctors Assist People Who WIsh to End Their Lives?
Guidelines, LLMs, and the Laundering of Uncertainty
Four Ways to Decrease Overall Mortality
When do you need a disease expert and when do you need a data expert?
This Fortnight in Medicine XXX
Is Universal Testing for Lp(a) Warranted?
Can AI tell you who needs an ICD?
The Nuances of the Impact Factor
Semi-automated offsides technology and diagnostic expansion medicine
I am torn on the PolyPill concept
Turning Three Pet Peeves into Unsolicited Advice
How investigators, journalists, and editors contribute to mistrust in science
This Fortnight in Medicine XXIX
When Normal Isn’t Normal: Non-anemic Iron Deficiency
A Medical Reversal You May not Have Heard Of
Friday Reflection 62: The Ethics of Telling Patients We Have Nothing Left to Offer
The SNAP Trial Exemplifies What EBM Should Look Like
Why has trust in medicine declined?
Genetic Screening of Newborn Babies
This Fortnight in Medicine XXVIII
Closing the loop on Hantavirus
For Hospital Medicine, the Answer Should Always be: Randomize
The American Diabetes Association Threw Out Researchers for Passing Out Their Editorial
Clinical Trial Prediction Markets: Forecasting Evidence or Distorting It?
I'm healthy. I'm a little overweight. Should I start a GLP-1?
Behind Every Dad Bod is a Dad Brain?
Do not assume beneficial interventions apply to higher-baseline risk patients
Should evidence come with an expiration date?
Treating (or not treating) the Sick, the At-risk, the Well, and the Hobbyists
Ferritin Levels – Redefining Normality in Women
This Fortnight in Medicine XXVII
Good Ideas Need to Pass Muster in the RCT
How to Keep up with the Medical Literature
ChatCPR: AI’s Answer to the Question ‘When Will It Save Lives?’
Affirmative Action in Medical Education
When Sponsors Stop Trials Everyone Loses
Friday Reflection 60: The Brockton
Aggressive Cholesterol Management
This Fortnight in Medicine XXVI
If not for placebo procedures, you might be getting holes drilled into your heart
When does shared decision-making mean recommending ineffective therapies?
Hantavirus, What You Need to Know
I Invented a Headache to Test AI. Here’s What I Found.
Evidence Appraisal Is NOT like a Rorschach Test
Shortening Medical School Will Not Improve Medical Education
This Fortnight in Medicine XXV
Bravery (and Humility) is Needed to do Proper Medical Science
How to Avoid Giving a Crap Lecture
“It’s in the new guidelines” does not always mean it’s time to change practice.
Nirmatrelvir for Vaccinated or Unvaccinated Adult Outpatients with Covid-19
“Doc, I got a MyChart alert that I am due for an RSV vaccine, can I get it today?”
This Fortnight in Medicine XXIV
The Hubris of Screening for Disease -- Again
Long COVID. Alzheimer’s. You Choose.
Friday Reflection 61: Private-Mini-Memorials
An observational study for left atrial appendage closure supports CLOSURE AF data
Guidelines, Evidence-based Medicine, and the Practice of Medicine
This Fortnight in Medicine XXIII
The Illusion of Progression-Free Survival
At ACC26, the HI-PEITHO Trial is in a Photo-Finish for Greatest Spin
A Referendum on the Self: On Entering the Medical Profession
Hyponatremia, Observational Studies, and Changing Practice
CHAMPION AF Breaks Almost Every Rule of Noninferiority Trial Design
Another Case of Medicine Gone Wrong
This Fortnight in Medicine XXII
The Salt Paradox: Essential Mineral, Silent Threat, or Something In Between?
When Surrogate Endpoints Best the Primary Endpoint
Friday Reflection 59: Healing Rather than Treating
When Every Scan Is Free: The Tragedy of the Diagnostic Commons
The Problem of Incidental Coronary Artery Calcium on a CT Scan
Notes on Being a Deeply Fulfilled Workist
The Continuing Stream of Exercise Churnalism
This Fortnight in Medicine XXI
Incentives and Noninferiority Designs
Breaking News: I found a good observational study
Don’t ‘Break up Big Medicine’, Instead ‘Level the Playing Field’ and ‘Change the Game’.
The CV of Failures and the Unplanned Career Path
Last week I saw the end result of a biased trial, lax regulation, absent peer review and groupthink
Friday Reflection 58: COVID-19, Six Years On
A Little More on those Three Letters -- PSA
Primary prevention, statins, lottery effects and misinformation that is not actually misinformation
Alternative Modalities for Breast Cancer Screening
Tomosynthesis vs Digital Mammography Screening in Women with a Family History of Breast Cancer
Why Blood Tests Are a Poor Screening Tool for Alzheimer’s
Coffee is great but it does not prevent dementia
The Trouble with Treating the Future: Elevated Lipids, Low Risk, and the Making of Patients
In Honor of the Three Greatest Words in the English Language
The Doctor Won’t See You Now—Should You Worry?
This Fortnight in Medicine XIX
Initial Impressions of the LIBERATE-D Trial
Friday Reflection 57: Aging Is Not a Medical Problem
More Bad News for modRNA Vaccines
On the Conservation of Primary Care Physicians
The tension between expertise and convenience in complex medical care
Not a Bitter Pill to Swallow: A Simple Fix to Quell the Flu
This Fortnight in Medicine XVIII
How Good is the Apple Watch at Detecting Hypertension?
Exercise is great but exercise studies...not so much
Friday Reflection 56: Comments that Stuck
Another Thing That's Undeniably Improved in Medicine: Getting an HIV Test
Prostate Cancer Screening: Lessons from Plato on Justice and Communication
FAME-2: One of cardiology's most influential trials, and, one of its most flawed
When to treat (or not treat) a high cholesterol
Learning Medicine Requires Learning a New Language
The Best Studies of 2025 for Hospital Medicine
This Fortnight in Medicine XVII
2024-2025 COVID-19 Vaccine Effectiveness in Pediatric Patients: A Response
Food may be medicine but it is not an easy one to give nor is it very effective
Why Healthcare Commentators (and Doctors) are Afraid of the Free-Market
A Trial of a Novel modRNA Flu Shot: Not So Hot
Who Do You Want at a Family Picnic?
Prevention is a challenge in younger patients; it’s near impossible in older patients