Sitemap - 2025 - Sensible Medicine

How Not to Get Fooled by the Medical Literature - Part 5 Placebo Effect and Sham Interventions

A Standing Ovation for CHALLENGE

Marketing Disguised as Science Embarrasses Everyone Involved

The Etiology of Denial

Advice for Internship

Primum Non Nocere

This Fortnight in Medicine (Episode II)

Randomized Trials Should Determine Causality and Be Useful in the Clinic—But Sometimes Accomplish Neither

Residency’s First Life Lesson

Subjectivity, RCTs, Exercise, and Colon Cancer

The NIH Just Canceled Funding for HIV Vaccine Research – Is That Wrong?

How Not to Get Fooled by the Medical Literature - Part 4 Diagnostic Tests

Good Ideas Require Testing – The Lessons of the NUDGE CKD Trial

Another Note on Disagreement

Six Reasons to Become a Dermatologist

Why Clean Drinking Water is Overrated

White Coats, Fomites, and Surrogate Endpoints

Can We Give the New FDA Leadership a Chance

This Fortnight in Medicine

Rotavirus Vaccination Deserves Nuanced Discussion

Exercise is Great but It’s Not a Cancer Drug

The Patch of Nothingness

Underappreciated Harms of the Electronic Medical Record

How Not to Get Fooled by the Medical Literature - Part 3 : Bad Observational Epi & a Flawed Randomized Trial

Merch...

The MAHA Report: A Seismic Shift in US Health Policy

The Problem with Pragmatic Trials

When guidelines do not match the evidence--the story of beta-blockers after MI

Comparing the Healthcare and Airline Industries

Underappreciated Harms of the Electronic Medical Record

FDA Town Hall Video with Prasad and Makary

Prasad, Makary, and An Evidence-Based Approach to Covid-19 Vaccination

The Lessons of Day vs Night Administration of BP Medications

Ask Us Anything

The Guy in Room 20

Diseases Just Learned: Part 2

How Not to Get Fooled by the Medical Literature - Part 2: Observational Studies

Tricuspid Valve Interventions and its Dubious Evidence

I Learned About Medicine From That

Diseases Just Learned: Part 1

Vinay at FDA; what's next for Sensible Medicine; ask us anything answers

Sensible Medicine endorses Vinay Prasad for Director of the Center for Biologics Evaluation and Research (CBER) at the US FDA

Two Important Concepts in Medical Practice Emerged from the Comments Yesterday

Perhaps the Strongest Benefit of GLP1a drugs is...

Defining the Risk of Oral Tobacco Products

Caring for Patients, Not Judging Them

How Not to Get Fooled by the Medical Literature - Part 1 - Course Introduction

The NIH Can Launch its Autism Research Initiative Immediately

Words can Harm, Words can Heal

When Death Comes to the Intensivist

Abortion, Vaccines, and Autism

How Not to Give a Crappy Lecture

What Fictional Dramas Can Tell Us About the Post COVID Pandemic Narratives

Ask Us Anything: Chapter 2

When a "negative" trial causes confusion -- back to the story of cerebral embolic protection devices

What We've Learned From Sensible Medicine

What if it were the other way around: Universities were overwhelmingly conservative and shut down liberal ideas & faculty for years

Death and the Older Internist

Choosing the Diagnosis

I Learned About Medicine From That: The Wizard of Oz Revealed

Vaccine analyses in nonsensible times

Tech Bros Require Regular Relooks at the Seminal Evidence in Coronary Artery Disease

Are medical journals balanced?

Adam Cifu, Churnalist

Post Herpetic Churnalism

Should Physicians Follow Hollywood's Script?

I learned about medicine from that: aboard the La Rabida Children's hospital

I've been wrong about treating pleural effusion for 25 years

Intern Year: A Resident’s Reflections and Advice

A Call for Parentalism in Medicine

I learned about medicine from that: But... But....."Aaron has the broken arm!"

Supporting Third Stage Academic Medicine Physicians

The False Narrative of Nonspecific Vaccine Effects

I Learned About Medicine From That: the first patient I cared for who died

Artificial Intelligence can be the Catalyst for Transformative Change at NIH

When A Negative Trial Takes 11 Years to Publish

Why Executive Health Physicals Make Me Nuts

Spreadsheets, Meetings, Lunches, and Paychecks

Why shadowing Vinay Prasad convinced me to become an oncologist

The IAMI Study: The Forgotten Influenza Vaccine Trial

How a Meta-Analysis can Mislead—The Story of Complete vs Culprit-only PCI in STEMI

Vaccine Injured and Ignored

Sepsis Screening Decreases Mortality. Well, not really.

Making a Connection

2025 - COVID-19 Vaccine Variant Target: Who Should Choose?

Planned Home Birth - Marty Makary’s Blind Spot

Coronary Artery Calcium Trial Fails to Impress

Who should serve on the vaccine advisory committee (ACIP)?

Friday Reflection 48: Linguistics, Diagnosis, and Medical Error

Blood, shit, piss and pus

Honoring Henry Marsh's 75th Birthday

Six Urban Myths About Smoke-Free Nicotine

Duration of Trials vs Duration of Therapy

The NIH is Being Slashed and Burned, not “Reformed”

Advice for Your Clinical Clerkships

Questioning Coverage for Coronary Artery Scans

The Hidden Cost of Sports Betting: A Public Health Crisis in the Making

KOLs boost Early Aortic Valve Intervention in Patients with Asymptomatic AS--Despite Dubious Evidence

Idaho considers withdrawing from WWAMI because UWash has "become political"

Whining Doctors and the Patients They Whine About

Why most medical research is likely (still) waste, and less research funding may be one way forward

What I Read Last Week

Antibiotic Management of Nonperforated Appendicitis is Inferior to Appendectomy

A new, costly cancer drug vs placebo; Cabozantinib in neuroendocrine tumors; How NIH funded trials can fail patients and payers

Prometheus and The Worried Well

Active and Passive Academic Freedom

In Honor of the Three Greatest Words in the English Language

Cutting NIH Indirects is Sensible Medicine

Medical Student Research

Should RFK Jr be confirmed?

Recent News Headlines Imply that Cannabis is Deadly

A Conversation with Professor Jeffrey Flier Regarding Changes in NIH Funding

What has gotten better and what has gotten worse since you started in medicine

You read an article you disagree with on Sensible Medicine: What next?

A Plan to Refocus Primary Care

RFK Jr hearings/ Eulogy Values & NIH delays

A review of the newly approved novel non-opioid pain reliever suzetrigine (Journavx)

Randomize NIH grant giving

Race in Medicine

Zombie Healthcare Masking Policies Return to Maryland

What Drug Was Worth More Than Half a Billion Dollars to Advertise Directly to Consumers?

Is RFK Jr to blame for the Samoa measles outbreak? An empirical analysis of published scholarly papers and news stories

When Trials Find Implausible Results—The SCOT-HEART trial

Eulogy versus Resume Virtues

A Conversation with Michael Easter from the TWO/PERCENT

We Need Research that Answers Important Questions

Seed Oils: Real Harm or Just Another Food Fear Fad?

The War On Abortion Is The New War On Drugs

The Pros and Cons of Studying Strategies with RCTs - EAST AFNET 4

The nomination of Robert F. Kennedy Jr. as Secretary of the Department of Health and Human Services: a new beginning?

In the wake of the surgeon general’s guidance on alcohol, what advice do you give your patients about drinking?

Robert F. Kennedy Jr. and the Treatment of Drug Addiction

The Case for Pardoning Fauci

PROFID EHRA: The Most Important Trial of the Decade in Cardiology

To Improve Public Trust, the CDC Should Embrace Nuance

Friday Reflection 47: Patients Make the Hardest Decisions

X's Community Notes Are a Model for Public Health Success—Will Meta Actually Follow Suit?

A conversation with Margaret McCartney, MD, PhD regarding evidence-based medicine and conflicts of interest

On Euthanasia and Medicine

Drug-eluting coronary stents: a masterclass in (broken) evidence translation?

A Very Tepid Defense of the Physical Exam

In Search of Motives

Scourges of the '70s, Defeated!